Does Vitamin C Deficiency Affect Cognitive Development and Function?

نویسندگان

  • Stine Normann Hansen
  • Pernille Tveden-Nyborg
  • Jens Lykkesfeldt
چکیده

Vitamin C is a pivotal antioxidant in the brain and has been reported to have numerous functions, including reactive oxygen species scavenging, neuromodulation, and involvement in angiogenesis. Absence of vitamin C in the brain has been shown to be detrimental to survival in newborn SVCT2(-/-) mice and perinatal deficiency have shown to reduce hippocampal volume and neuron number and cause decreased spatial cognition in guinea pigs, suggesting that maternal vitamin C deficiency could have severe consequences for the offspring. Furthermore, vitamin C deficiency has been proposed to play a role in age-related cognitive decline and in stroke risk and severity. The present review discusses the available literature on effects of vitamin C deficiency on the developing and aging brain with particular focus on in vivo experimentation and clinical studies.

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عنوان ژورنال:

دوره 6  شماره 

صفحات  -

تاریخ انتشار 2014