Does Vitamin C Deficiency Affect Cognitive Development and Function?
نویسندگان
چکیده
Vitamin C is a pivotal antioxidant in the brain and has been reported to have numerous functions, including reactive oxygen species scavenging, neuromodulation, and involvement in angiogenesis. Absence of vitamin C in the brain has been shown to be detrimental to survival in newborn SVCT2(-/-) mice and perinatal deficiency have shown to reduce hippocampal volume and neuron number and cause decreased spatial cognition in guinea pigs, suggesting that maternal vitamin C deficiency could have severe consequences for the offspring. Furthermore, vitamin C deficiency has been proposed to play a role in age-related cognitive decline and in stroke risk and severity. The present review discusses the available literature on effects of vitamin C deficiency on the developing and aging brain with particular focus on in vivo experimentation and clinical studies.
منابع مشابه
P 80: Effects of Vitamin D on Migraine
Migraine is a disabling headache disorder. That is characterized by recurrent unilateral pulsatile headaches. It is one of the most common neurological disorder in the world that nearly one billion of people are affected by migraines. The main Migraine’s features are headaches. Accompanying symptoms are nausea, sometimes vomiting, photophobia, neck pain and muscle tension. Its attacks las...
متن کاملVitamin B12 and cognitive function: an evidence-based analysis.
BACKGROUND More than 2.9 million serum vitamin B12 tests were performed in 2010 in Ontario at a cost of $40 million. Vitamin B12 deficiency has been associated with a few neurocognitive disorders. OBJECTIVE To determine the clinical utility of B12 testing in patients with suspected dementia or cognitive decline. METHODS Three questions were addressed: Is there an association between vitamin...
متن کاملVitamin D deficiency and stroke
Vitamin D comprises a group of fat-soluble pro-hormones, obtained from sun exposure, food, and supplements, and it must undergo two hydroxylation reactions to be activated in the body. Several studies have shown the role of vitamin D in mineral metabolism regulation, especially calcium, phosphorus, and bone metabolism. Some factors such as inadequate vitamin intake and liver or kidney disorders...
متن کاملVitamin B12, cognition, and brain MRI measures: a cross-sectional examination.
OBJECTIVE To investigate the interrelations of serum vitamin B12 markers with brain volumes, cerebral infarcts, and performance in different cognitive domains in a biracial population sample cross-sectionally. METHODS In 121 community-dwelling participants of the Chicago Health and Aging Project, serum markers of vitamin B12 status were related to summary measures of neuropsychological tests ...
متن کاملIs there convincing biological or behavioral evidence linking vitamin D deficiency to brain dysfunction?
Vitamin D insufficiency is common in the United States; the elderly and African-Americans are at particularly high risk of deficiency. This review, written for a broad scientific readership, presents a critical overview of scientific evidence relevant to a possible causal relationship between vitamin D deficiency and adverse cognitive or behavioral effects. Topics discussed are 1) biological fu...
متن کامل